The game features bosses at the end of each level, which the player must defeat in order to progress. The player can also find and use various power-ups, such as extra web fluid and health-restoring spider symbols. The game is a side-scrolling beat 'em up in which the player controls Spider-Man as he fights his way through various levels, using his webs and acrobatic abilities to defeat enemies.
The game features the titular character Spider-Man attempting to stop his archenemy, Venom, from orchestrating a city-wide crime spree with the help of several other supervillains. It is based on the "Spider-Man" comics published by Marvel Comics, specifically the "The Venom Saga" story arc.
"Venom: Spider-Man: Separation Anxiety" is a video game released in 1995 by Acclaim Entertainment for the Super Nintendo Entertainment System and Sega Genesis/Mega Drive.